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"Association of Omicron vs Wild-type SARS-CoV-2 Variants With Hospital-Onset SARS-CoV-2 Infections in a US Regional Hospital System"

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Purifier manufacturers typically recommend replacing them annually, but check the manual: Some models call for less frequent or more frequent replacement

The evidence was insufficient to specify which design changes have been responsible for this increased risk, but suggests that filter ventilation (see Sections 12.8.2.3 and 12.8.2.4 below) and higher levels of tobacco-specific nitrosamines (Section 12.4.3.7) were highly influential